The Future Doesn’t Fit in Boxes. Neither Do We.
At H Tree, we believe the world is too vast, too intricate to be confined by labels. Sure, as people we love categories – drawing lines on maps and calling them countries, studying people’s habits and calling them personalities – but the most exciting breakthroughs happen when we break free from those boxes. And that’s exactly where we operate: at the intersection of computation and biology.
People often ask us: “What’s your investment thesis?” The name H Tree offers a clue. Inspired by watching my young son study a book on fractals found in nature, the name reflects the repeating patterns found in both nature and computer science. The same forces shaping tree branches and river deltas also power cutting-edge algorithms. This is where we thrive—where silicon meets cell, where code meets creation.
We’re geeks. Proud ones. We know our algorithms and our amino acids. And we see a huge opportunity ahead: a future where computation and biology converge to unlock extraordinary possibilities. This isn’t science fiction—it’s happening now.
Our fund focuses on this thrilling convergence! We live in an era where genomics produces more data than ever imagined, quantum computing tackles puzzles Einstein couldn’t solve, and AI deciphers protein folding that confounded biologists for decades. A decade ago, it took a year and a team of scientists to deliver what now lands in our inboxes each morning. This isn’t Moore’s Law anymore—it’s a whole new velocity.
Machine learning is mapping molecular behaviors, designing materials, and optimizing energy systems that will transform industries—and even save our planet. Machine learning doesn’t just process data; it discovers drugs, predicts climate shifts, and re-engineers agriculture from the soil up. The future isn’t waiting – it’s already here, shaped by visionary founders disrupting how we live, age and impact our planet.
In human health, we hunt for value from laboratory bench to hospital bedside. Early in the chain, biology leads the dance and computation follows – like in drug discovery, where algorithms serve as microscopes into cellular mysteries. But, follow the chain up through clinical trials and commercialization, and computation takes the lead, orchestrating vast networks of data and decision.
For planetary health, we invest in founders who harness nature’s four billion years of R&D and supercharge it with technology. From scaling enzyme-based carbon capture solutions to revolutionizing precision agriculture with AI-driven systems that replace veterinary antibiotics, lower fertilizer use and boost crop yields—these aren’t just ideas; they’re nature’s patents, applied at scale to solve human challenges. The markets are massive. The solutions? Ingenious.
Our team embodies this mission. My partner and I have been in the trenches for over 15 years—whether working with silicon or cells, we’ve built the networks and gained hands-on experience in both worlds. We know the landscape because we’ve traversed it ourselves.
We’re building something different here—something that doesn’t fit into old boxes or wear traditional labels. We live in the space between disciplines, where the most groundbreaking high impact opportunities always lie. That’s where you’ll find us. And that’s where we’ll find the future.
By Vanela Bushi, Co-founder and General Partner